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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

Fig. 1

Effects of dual block of anti-HER2 inhibitors alone and/or in combination with anti-EGFR and anti-HER3 mAbs on HER2-amplified (SW48-HER2 and LIM1215-HER2) human colon cancer cells. a-e Cells sensitivity to different drugs was evaluated by clonogenic assay in LIM1215-HER2 and SW48-HER2 cells. Data were represented as cell colony area calculated by ImageJ software after staining with crystal violet, as described in Materials and Methods. e Table with IC50 value for each drug, used as single agent or in combination

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