Fig. 11From: Nek2B activates the wnt pathway and promotes triple-negative breast cancer chemothezrapy-resistance by stabilizing β-cateninThe activity of TOP/FOP was detected after Nek2B-siRNA or Nek2B plasmid were transfected to the cell lines Hs578T and BT20 (a) or MDA-MB-231 and 468 (b), respectively; PCR and westem blot assay were used to detect the expression of downstream target genes of wnt pathway after Nek2B-siRNA was transfected to Hs578T cells (c) and Nek2B plasmid were transfected to MDA-MB-231 cell (d). *P<0.05; **P<0.01Back to article page