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Fig. 12 | Journal of Experimental & Clinical Cancer Research

Fig. 12

From: Nek2B activates the wnt pathway and promotes triple-negative breast cancer chemothezrapy-resistance by stabilizing β-catenin

Fig. 12

Nek2B activates the wnt pathway by stabilizing β-catenin. Control, Nek2B, Nek2B + sh-control or Nek2B+ sh-β-catenin plasmids were transfected into MDA-MB-231 cell lines, and the expression levels of TOP/FOP reporting system (a) and the downstream target genes c-myc, cyclinDl and Axin2 of wnt signaling pathway were detected (b) respectively;(c) Transwell cell invasion experiment was used to verify the changes in the invasion ability of MDA-MB-231 cell line after transfection of control, Nek2B, Nek2B + sh-control or Nek2B + sh-β-catenin plasmids. *P<0.05; **P<0.01

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