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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis

Fig. 2

Triptolide inhibits tumorigenesis in ApcMin/+ mice and disrupts organoid growth. a The workflow of the triptolide treatment in the ApcMin/+ mouse model. b The small intestines from 6-month-old ApcMin/+ mice treated with or without triptolide for 3 months. Scale bar: 1 cm. c H&E staining of the small intestines from 6-month-old ApcMin/+ mice treated with or without triptolide for 3 months. Scale bar: 1 mm. Tumor number and size distribution from ApcMin/+ mice treated with or without triptolide were analyzed. ** P < 0.01. d Organoids isolated from ApcMin/+ mice were treated with or without 5 nM of triptolide and pictures were taken under a microscope. Scale bar: 25 μm. Organoids were treated with different concentration of triptolide for 72 h and cell viability (ATP level) was measured. ** P < 0.01

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