Fig. 8

a Indicated transcription factors (TFs) may directly bind to the promoter of the IL-10 gene. b-d Expression of the indicated TFs in nuclei of indicated HCC cells by Western blotting. e Expression of CREB protein in HIG2-silenced HCC cells (e). f–h Flow cytometry, LDH detection and Qrt-pcr were performed to analyse the restoration of CREB for the phenotype of HIG2-silenced HCC cells or the expression of IL-10