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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: miR-126-3p down-regulation contributes to dabrafenib acquired resistance in melanoma by up-regulating ADAM9 and VEGF-A

Fig. 7

miR-126-3p replacement impairs invasiveness of dabrafenib-resistant cells. a, b Melanoma cells were transiently transfected with 50 nM pre-miR-126-3p or pre-miR-CTRL and 24 h later incubated with 100 nM dabrafenib (DAB) or DMSO alone. After additional 48 h of culture, the cells were assayed for ECM invasion. Left panels, percentage of invaded cells with respect to DMSO-treated/pre-miR-CTRL-transfected cells. Each value represents the arithmetic mean of four (A375R) or three (SK-Mel28R) independent experiments performed with triplicate samples. Bars, SEM. ##P<0.01, pre-miR-126-3p/DMSO vs pre-miR-CTRL/DMSO; §§P<0.01 and §P<0.05, pre-miR-126-3p/DAB vs pre-miR-CTRL/DAB; **P<0.01 and *P<0.05, DAB vs matched DMSO. Right panels, representative images of polycarbonate filters with invaded melanoma cells.

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