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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: RETRACTED ARTICLE: Down-regulated lncRNA DLX6-AS1 inhibits tumorigenesis through STAT3 signaling pathway by suppressing CADM1 promoter methylation in liver cancer stem cells

Fig. 7

Decreased lncRNA DLX6-AS1 represses tumorigenicity and progression of tumors of LCSCs in vivo through inhibiting the activation of the STAT3 signaling pathway by up-regulating CADM1. a, proportion of stem cells in mice of 6 groups determined by LDA; b, size of subcutaneous tumor in mice of 6 groups detected by tumor xenograft in NOD-SCID mice; c, mass of subcutaneous tumor in mice of 6 groups; d, volume of subcutaneous tumor in mice of 6 groups; N = 8; *, p < 0.05, vs. the blank group; the statistical data were expressed as mean value of standard error and analyzed by one-way ANOVA; the experiment was conducted 3 times; ANOVA, analysis of variance; CADM1, cell adhesion molecule 1; STAT3, signal transducer and activator of transcription 3; LDA, limiting dilution assay; LCSCs, liver cancer stem cells; lncRNA, long non-coding RNA; DLX6-AS1, DLX6 antisense RNA 1

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