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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer

Fig. 4

NEO212 promotes mitochondrial dysfunction. a A2780 and SK-O-V3 cells treated with 100 μM TMZ, POH, TMZ + POH, NEO212 or DMSO for 48 h respectively were stained with MTG. Scale bars: 10 μm. b-c Mitochondria structure in A2780 and SK-O-V3 cells treated with 100 μM NEO212 or DMSO was observed by TEM. Scale bars: 0.5 μm. Mitochondrial shape and area were measured using Fiji Image J. d A2780 and SK-O-V3 cells were treated with 100 μM TMZ, POH, TMZ + POH, NEO212 or DMSO for 48 h respectively, and detected using JC-1 flow cytometry. The results shown are means ± SD; *p < 0.05; **p < 0.01; ***p < 0.001, NS = no significance

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