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Table 1 Change of sensitivity of the HCT-8 cells to chemotherapeutic drugs after the treatment of 3 μM ivermectin

From: Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

Test drugs IC50 (μM) Sensitivity ratios
S R [IC50 (- IVM)/IC50 (+ IVM)]
- IVM + IVM - IVM + IVM S R
Vincristine 0.081 ± 0.001 0.027 ± 0.001 1.015 ± 0.003 0.032 ± 0.001 2.96 31.15
Mitomycin C 2.71 ± 0.32 1.34 ± 0.22 26.62 ± 0.51 4.81 ± 0.32 2.02 5.53
Adriamycin 5.42 ± 0.34 0.42 ± 0.12 36.34 ± 0.93 0.74 ± 0.14 12.90 49.11
  1. Abbreviations: S, vincristine-sensitive HCT-8 cells; R, vincristine-resistant HCT-8 cells; IVM, ivermectin