Table 2 Correlation between the clinicopathologic characteristics and membranous, cytoplasmic and nuclear expression of β-catenin in 283 breast cancer patients
Parameters | Cases | β-catenin(M) | p | β-catenin(C/N) | p | ||
|---|---|---|---|---|---|---|---|
Normal (N, %) | Abnormal (N, %) | Negative(N, %) | Positive (N, %) | ||||
Age(yr) | 160(56.5) | 123(43.5) | 62(21.9) | 221(78.1) | |||
≤50 | 130 | 79(49.4) | 51(41.5) | 0.186 | 32(51.6) | 123(55.7) | 0.310 |
> 50 | 153 | 81(50.6) | 72(58.5) | 30(48.4) | 98(44.3) | ||
Menopausal status | |||||||
Premenopausal | 156 | 90(56.3) | 66(53.7) | 0.664 | 37(59.7) | 119(53.8) | 0.415 |
Postmenopausal | 127 | 70(43.8) | 57(46.3) | 25(40.3) | 102(46.2) | ||
Family history | |||||||
No | 194 | 111(69.4) | 83(67.5) | 0.734 | 69(31.2) | 152(68.8) | 0.877 |
Yes | 89 | 49(30.6) | 40(32.5) | 20(32.3) | 69(31.2) | ||
Tumor size | |||||||
T1 | 110 | 66(41.3) | 44(35.8) | 0.428 | 32(51.6) | 78(35.3) | 0.055 |
T2 | 149 | 83(51.9) | 66(53.7) | 27(43.5) | 122(55.2) | ||
T3 | 24 | 11(6.9) | 13(10.6) | 3(4.8) | 21(9.5) | ||
Histological grade | |||||||
1 | 44 | 33(20.6) | 11(8.9) | 0.005* | 16(25.8) | 28(12.7) | 0.029* |
2 | 153 | 88(55.0) | 65(52.8) | 32(51.6) | 121(54.8) | ||
3 | 86 | 39(24.4) | 47(38.2) | 14(22.6) | 72(32.6) | ||
LN involvement | |||||||
0 | 180 | 114(71.3) | 66(53.7) | 0.018* | 49(79.0) | 131(59.3) | 0.028* |
1–3 | 43 | 19(11.9) | 24(19.5) | 7(11.3) | 36(16.3) | ||
4–9 | 41 | 20(12.5) | 21(17.1) | 5(8.1) | 36(16.3) | ||
≥ 10 | 19 | 7(4.4) | 12(9.8) | 1(1.6) | 18(8.1) | ||
ER | |||||||
Negative | 111 | 68(42.5) | 43(35.0) | 0.198 | 27(43.5) | 84(38.0) | 0.430 |
Positive | 172 | 92(57.5) | 80(65.0) | 35(56.5) | 137(62.0) | ||
PR | |||||||
Negative | 142 | 87(54.4) | 55(44.7) | 0.107 | 35(56.5) | 107(48.4) | 0.263 |
Positive | 141 | 73(45.6) | 68(55.3) | 27(43.5) | 114(51.6) | ||
Her-2 | |||||||
Negative | 200 | 109(54.5) | 91(45.5) | 0.283 | 44(22.0) | 156(78.0) | 0.953 |
Positive | 83 | 51(61.4) | 32(38.6) | 18 (21.7) | 65 (78.3) | ||
Ki67 | |||||||
< 20 | 83 | 54 (33.8) | 29 (23.6) | 0.062 | 19 (30.6) | 64 (29.0) | 0.797 |
≥ 20 | 200 | 106 (66.3) | 94 (76.4) | 43 (69.4) | 157 (71.0) | ||
P53 | |||||||
Negative | 143 | 80(50.0) | 63(51.2) | 0.839 | 27(43.5) | 116(52.5) | 0.213 |
Positive | 140 | 80(50.0) | 60(48.8) | 35(56.5) | 105(47.5) | ||