Fig. 10

Schematic diagram of mechanism on this research. H. cordata and 2-undecanone could effectively activate the Nrf2 pathway to induce the expression of the antioxidative enzymes HO-1 and NQO-1 and thus to counteract intracellular ROS generation, thereby attenuating DNA damage and inflammation caused by B[a]P stimulation and playing a role in the chemoprevention of B[a]P-induced lung carcinogenesis