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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Houttuynia cordata Thunb. and its bioactive compound 2-undecanone significantly suppress benzo(a)pyrene-induced lung tumorigenesis by activating the Nrf2-HO-1/NQO-1 signaling pathway

Fig. 3

H. cordata and 2-undecanone protect BEAS-2B cells from B[a]P-induced cell cycle arrest. The cell cycle was examined by PI staining. The percentages of cell cycle arrest were analyzed by flow cytometry (a) and by analysis of the expression of cyclin D1 in cells after treatment with H. cordata (12.5, 25, or 50 mg/mL) (b) or 2-undecanone (25, 50, or 100 μM) (c) for 48 h in the presence or absence of B[a]P (5 μM). The data represent the mean ± SD (n = 3). ##p < 0.01 and ###p < 0.001 compared with the control cells (given water); *p < 0.05, **p < 0.01, and ***p < 0.001 compared with the model cells (given B[a]P)

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