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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway

Fig. 1

AKR1C1 expression correlates to cisplatin response and functions as a poor prognostic marker in HNSCC. a Hierarchical clustering of differentially expressed genes between cisplatin IC50 from GDSC and gene expression profiles from CCLE. Note that AKR1C1 and C2 are highly correlated with cisplatin IC50. b HNSCC cisplatin IC50 value from the GDSC database. c AKR1C1 expression was correlated with a poor survival rate in HNSCC patients in the TCGA (Upper panel, n = 519, HR = 1.84, p = 0.035) and a short recurrence-free time from the GSE10300 HNSCC cohort (Bottom panel, n = 44, HR = 1.76, p = 0.041) from the SurvExpress database. d and e. Expressions of AKR1C1 were assessed by immunoblotting (d) and RT-Q-PCR (e) in the indicated cell lines. f and g. The AKR1C1 (f) andAKR1C2 (g) mRNA expression level in Cal-27 cells with or without cisplatin treatment. The statistical significance was analyzed by Student’s t-test. **p < 0.01, ***p < 0.001

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