Fig. 7

Mechanistic diagram illustrates the signaling transduction of NF-kB/miR-130b~301b cluster/USP13 axis. NF-kB decreases USP13 expression by inducing the transcription of miR-130b/301b, thereby suppresses expression of PTEN. On the other hand, PTEN governs the activity of NF-kB by inhibiting the PI3K/AKT signaling. The regulatory loop of NF-kB-induced loss of PTEN expression promotes constitutive activation of NF-kB and tumorgenesis of bladder cancer