Fig. 1

Proteomic and gene expression analysis of samples from sensitive (S) and resistant (R) patients. a Principal Component Analysis (PCA) of 2D-DIGE-based proteomic analysis results (S = 20, R = 20). b Volcano plot. Data points above the horizontal blue line passed the P-value threshold of 0.05 (S = 16, R = 16). c Digital PCR results showing number of copies/μl for ANXA2, NDRG1 and STAT1 (S = 9, R = 10). d Comparison of DeltaCts (Ct target gene-Ct reference gene) obtained with RT-qPCR (S = 15, R = 13). *P < 0.05, **P < 0.01 refer to unpaired t-test with Welch’s correction for unequal variances between the S and R group, for each mRNA