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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: MET in glioma: signaling pathways and targeted therapies

Fig. 2

The regulation of MET expression and activation, and representative signal pathways associated with MET signaling. A. MiR-449-5b, miR-34a, miR-182, and miR-144-3p specifically bind the MET 3′-UTR region and inhibit MET transcription. Downregulation of these miRNAs upregulates the expression levels of MET. HSP90 facilitates the translation and modification of MET protein. B. Several other membrane proteins participate in the activation of MET; HAI-2 inhibits HGF-induced phosphorylation of MET, whereas CD44, GD3, and some other RTKs (EGFR, HER3, EGFRvIII) promote the phosphylation of MET, which ultimately promotes the tumorigenicity, proliferation, and invasion of glioma cells. C. MET signaling is associated with downstream signaling such as Wnt/β-catenin/Snail/Slug, NF-kB/CXCR4/SDF-1, PKCδ/SRC/STAT3/NOTCH2, Cox2/PGE2, ETS-1/MMP-14, and the stem cell transcription factor SOX2, all of which facilitate proliferation, migration, invasion, stem cell behavior, and aberrant vascularization in gliomas

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