Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer

Wu, Xiaosheng; Liu, Mengwei; Zhu, Huiqiong; Wang, Jing; Dai, Weiyu; Li, Jiaying; Zhu, Danping; Tang, Weimei; Xiao, Yizhi; Lin, Jianjiao; Zhang, Wenjing; Sun, Yong; Zhang, Yi; Chen, Yaying; Li, Guoxin; Li, Aimin; Xiang, Li; Liu, Side; Wang, Jide

doi:10.1186/s13046-019-1270-4

Journal of Experimental & Clinical Cancer Research

Table 1 iTRAQ ratios of up-regulated proteins in GC tissues

From: Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer

No.	Protein name	Gene name	Accession Number	Molecular Weight	Ratio
1	Muskelin	MKLN1	gi\|31,881,798	85 kDa	2.23
2	Polypeptide N-acetylgalactosaminyltransferase 13	GLT13	gi\|145,309,313	48 kDa	2.06
3	Keratin, type II cytoskeletal 1	K2C1	gi\|375,314,775	66 kDa	2.01
4	Keratin, type I cytoskeletal 9	K1C9	gi\|675,724,924	62 kDa	1.84
5	Ubiquitin carboxyl-terminal hydrolase 3	UBP3	gi\|55,770,886	59 kDa	1.54
6	Histamine N-methyltransferase	HNMT	gi\|5,901,970	33 kDa	1.53
7	Vomeronasal type-1 receptor 5	VN1R5	gi\|27,777,675	41 kDa	1.5
8	Kinesin-associated protein 3	KIFAP3	gi\|18,105,054	91 kDa	1.47
9	Zinc finger protein 592	ZN592	gi\|108,860,697	137 kDa	1.47
10	Otogelin-like protein	OTOGL	gi\|449,081,296	262 kDa	1.46
11	Period circadian protein homolog 2	PER2	gi\|6,683,645	137 kDa	1.43
12	Collagen alpha-3(IX) chain	CO9A3	gi\|426,392,464	63 kDa	1.39
13	RAS (RAD And GEM)-Like GTP-Binding 1	REM1	gi\|724,948,224	33 kDa	1.39
14	Coiled-coil and C2 domain-containing protein 2A	C2D2A	gi\|197,209,974	186 kDa	1.37
15	Kinesin-like protein KIF12	KIF12	gi\|85,541,032	71 kDa	1.36
16	Prostate stem cell antigen	PSCA	gi\|114,622,040	13 kDa	1.36
17	Conserved oligomeric Golgi complex subunit 2	COG2	gi\|6,678,676	83 kDa	1.36
18	Adenomatous polyposis coli protein	APC	gi\|53,759,122	312 kDa	1.35
19	Elongation of very long chain fatty acids protein 7	ELOV7	gi\|157,388,947	145 kDa	1.34
20	SH3 domain-binding protein 4	SH3B4	gi\|7,657,562	107 kDa	1.34
21	Keratin, type II cytoskeletal 5	K2C5	gi\|119,395,754	62 kDa	1.31
22	Retinoblastoma-associated protein	RB	gi\|108,773,787	106 kDa	1.31
23	Serine/threonine-protein kinase ULK3	ULK3	gi\|656,214,624	31 kDa	1.3
24	Zinc finger protein 469	ZN469	gi\|188,536,004	410 kDa	1.3
25	Kinetochore protein Spc25	SPC25	gi\|10,190,716	26 kDa	1.3
26	Shugoshin 2	SGO2	gi\|229,892,306	145 kDa	1.3
27	POTE ankyrin domain family member I	POTEI	gi\|475,808,427	121 kDa	1.29
28	Myelin expression factor 2	MYEF2	gi\|296,439,294	64 kDa	1.28
29	Mucolipin-3	MCLN3	gi\|24,496,763	64 kDa	1.28
30	Putative heat shock protein HSP 90-beta 4	H90B4	gi\|61,104,915	56 kDa	1.28
31	U6 snRNA-associated Sm-like protein LSm4	LSM4	gi\|513,024,372	15 kDa	1.28
32	tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial	TR61B	gi\|222,831,587	53 kDa	1.27
33	Phosphatidate phosphatase LPIN1	LPIN1	gi\|387,528,011	99 kDa	1.27
34	Uncharacterized protein C1orf167	CA167	gi\|158,706,475	162 kDa	1.26
35	Nebulin	NEBU	gi\|635,377,472	772 kDa	1.26
36	SPRY domain-containing protein 3	SPRY3	gi\|14,249,554	31 kDa	1.26
37	Nuclear receptor 2C2-associated protein	NR2CA	gi\|28,882,043	16 kDa	1.26
38	Charged multivesicular body protein 5	CHMP5	gi\|189,409,150	25 kDa	1.25
39	Collagen alpha-5(VI) chain	CO6A5	gi\|189,082,691	290 kDa	1.25
40	Dedicator of cytokinesis protein 11	DOC11	gi\|145,699,123	215 kDa	1.25
41	BPI fold-containing family A member 3	BPIA3	gi\|109,627,654	28 kDa	1.25
42	Obscurin	OBSCN	gi\|403,501,446	925 kDa	1.24
43	CCR4-NOT transcription complex subunit 6	CNOT6	gi\|28,872,863	63 kDa	1.24
44	5-methylcytosine rRNA methyltransferase NSUN4	NSUN4	gi\|40,316,918	49 kDa	1.23
45	Gamma-interferon-inducible lysosomal thiol reductase	GILT	gi\|6,165,618	28 kDa	1.23
46	POZ-, AT hook-, and zinc finger-containing protein 1	PATZ1	gi\|586,477,589	70 kDa	1.23
47	Suppressor of zest 12	SUZ12	gi\|197,333,809	83 kDa	1.23
48	MICOS Complex Subunit MIC27	MIC27	gi\|116,812,610	29 kDa	1.22
49	SPARC-related modular calcium-binding protein 1	SMOC1	gi\|11,545,873	48 kDa	1.22
50	Replication Termination Factor 2	RTF2	gi\|193,788,722	34 kDa	1.22
51	Poly(A) polymerase alpha	PAPOA	gi\|32,490,557	83 kDa	1.22
52	RNA-binding protein 42	RBM42	gi\|545,830,327	50 kDa	1.22
53	Platelet-activating factor acetylhydrolase IB subunit beta	PAFAH1B2	gi\|532,006,944	26 kDa	1.21
54	Ornithine decarboxylase antizyme 1	OAZ1	gi\|576,067,926	25 kDa	1.21
55	Zinc finger and BTB domain-containing protein 11	ZBT11	gi\|166,235,167	119 kDa	1.21
56	Methyltransferase-like protein 17, mitochondrial	MET17	gi\|12,232,389	50 kDa	1.21
57	Glycogen synthase kinase-3 beta	GSK3B	gi\|395,758,596	48 kDa	1.21
58	Thymosin beta-4	TYB4	gi\|112,180,578	5 kDa	1.21
59	Chromosome transmission fidelity protein 18 homolog	CTF18	gi\|27,501,458	129 kDa	1.21

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ISSN: 1756-9966

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