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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells

Fig. 3

MAGEA3 inhibits autophagy in growth factor deprived pancreatic cancer cells. a-b Immunoblot showing decreased autophagic marker LC3-II in cells ectopically expressed with MAGEA3 (a) and the same LC3-II is increased upon MAGEA3 knockdown in BxPC3 cells (b). Star above the bands indicates the leaky expression of MAGEA3. c, d Immunofluorescence staining showing endogenous LC3-II puntae (c, scale bar = 25 μm) and the bar graph showing the corresponding quantification using ImageJ software (d); *** = p < 0.001, n = 10

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