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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Viral integration drives multifocal HCC during the occult HBV infection

Fig. 5

Detection of CSMD2 and EXT1 expression in liver by IHC. Upper and lower panels show the analysis of CSMD2 and EXT1 expression by IHC staining in tumors, non-tumors, and PVTT from the same patient. CSMD2 is down-regulated and EXT1 is up-regulated in tumors and PVTT compared to non-tumor tissues (a). Additional 50 poorly differentiated liver tumors and the paired adjacent non-tumor tissues were acquired to confirm the findings (b). Wilcoxon signed rank test is used to determine the difference between tumors and non-tumors in CSMD2 expression (left panel) and EXT1 expression (right panel). CSDM2 scoring for adjacent non-tumor group as follows: n = 50, Median = 9, 25% Percentile = 6, 75% Percentile = 12, Mean = 8.1, SD = 3.5, SEM = 0.50; versus for tumor group as follows: n = 50, Median = 1, 25% Percentile = 0, 75% Percentile = 4, Mean = 2.7, SD = 3.4, SEM = 0.49. EXT1 scoring for non-tumor group as follows: n = 50, Median = 2, 25% Percentile = 0, 75% Percentile = 4, Mean = 2.12, SD = 2.06, SEM = 0.29; versus for tumor group as follows: n = 50, Median = 7, 25% Percentile = 4, 75% Percentile = 9.75, Mean = 6.86, SD = 3.86, SEM = 0.55

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