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Table 2 Clinicopathologic variables and the expression of FAM83H and β-catenin in osteosarcomas

From: FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas

Characteristics No. Cy-FAM83H Nu-FAM83H β-catenin
Positive P Positive P Positive P
Age, years
  <  30 24 8 (33%) 0.013 7 (29%) 0.07 8 (33%) 0.362
  ≥ 30 10 8 (80%)   8 (80%)   5 (50%)
Sex
 Male 24 13 (54%) 0.198 13 (54%) 0.068 10 (42%) 0.524
 Female 10 3 (30%)   2 (20%)   3 (30%)
Tumor size
  ≤ 8 cm 17 5 (29%) 0.039 4 (24%) 0.016 6 (35%) 0.724
  > 8 cm 17 11 (65%)   11 (65%)   7 (41%)
Tumor stage
 I 11 1 (9%) 0.002 0 (0%) < 0.001 2 (18%) 0.096
 II, III, IV 23 15 (65%)   15 (65%)   11 (48%)
Histologic grade
 1, 2 11 1 (9%) 0.002 0 (0%) < 0.001 2 (18%) 0.096
 3, 4 23 15 (65%)   15 (65%)   11 (48%)
Lymph node metastasis
 Absence 33 15 (46%) 0.282 14 (42%) 0.253 12 (36%) 0.197
 Presence 1 1 (100%)   1 (100%)   1 (100%)
Distant metastasis
 Absence 29 12 (41%) 0.110 11 (38%) 0.080 10 (34%) 0.278
 Presence 5 4 (80%)   4 (80%)   3 (60%)
β-catenin
 Negative 21 7 (33%) 0.042 5 (24%) 0.002   
 Positive 13 9 (69%)   10 (77%)   
FAM83H, nuclear
 Negative 19 3 (16%) < 0.001     
 Positive 15 13 (87%)     
  1. Abbreviations: Cy-FAM83H cytoplasmic expression of FAM83H, Nu-FAM83H nuclear expression of FAM83H