FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas

Table 2 Clinicopathologic variables and the expression of FAM83H and β-catenin in osteosarcomas

Characteristics	No.	Cy-FAM83H		Nu-FAM83H		β-catenin
Characteristics	No.	Positive	P	Positive	P	Positive	P
Age, years
< 30	24	8 (33%)	0.013	7 (29%)	0.07	8 (33%)	0.362
≥ 30	10	8 (80%)		8 (80%)		5 (50%)	0.362
Sex
Male	24	13 (54%)	0.198	13 (54%)	0.068	10 (42%)	0.524
Female	10	3 (30%)		2 (20%)		3 (30%)	0.524
Tumor size
≤ 8 cm	17	5 (29%)	0.039	4 (24%)	0.016	6 (35%)	0.724
> 8 cm	17	11 (65%)		11 (65%)		7 (41%)	0.724
Tumor stage
I	11	1 (9%)	0.002	0 (0%)	< 0.001	2 (18%)	0.096
II, III, IV	23	15 (65%)		15 (65%)		11 (48%)	0.096
Histologic grade
1, 2	11	1 (9%)	0.002	0 (0%)	< 0.001	2 (18%)	0.096
3, 4	23	15 (65%)		15 (65%)		11 (48%)	0.096
Lymph node metastasis
Absence	33	15 (46%)	0.282	14 (42%)	0.253	12 (36%)	0.197
Presence	1	1 (100%)		1 (100%)		1 (100%)	0.197
Distant metastasis
Absence	29	12 (41%)	0.110	11 (38%)	0.080	10 (34%)	0.278
Presence	5	4 (80%)		4 (80%)		3 (60%)	0.278
β-catenin
Negative	21	7 (33%)	0.042	5 (24%)	0.002
Positive	13	9 (69%)		10 (77%)
FAM83H, nuclear
Negative	19	3 (16%)	< 0.001
Positive	15	13 (87%)

Abbreviations: Cy-FAM83H cytoplasmic expression of FAM83H, Nu-FAM83H nuclear expression of FAM83H

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