Table 3 Univariate Cox proportional hazards regression analysis for the overall survival and relapse-free survival of osteosarcoma patients
From: FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas
Characteristics | No. | OS | RFS | ||
|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | ||
Age, years, ≥ 30 (vs. < 30) | 10/34 | 2.730 (1.01–7.377) | 0.048 | 2.959 (1.134–7.701) | 0.027 |
Sex, male (vs. female) | 24/34 | 1.900 (0.537–6.719) | 0.320 | 2.223 (0.629–7.857) | 0.215 |
Tumor size, ≥ 8 cm (vs. < 8 cm) | 17/34 | 4.301 (1.369–13.508) | 0.012 | 3.901 (1.351–11.260) | 0.012 |
Stage, ≥ II (vs. I) | 23/34 | 10.462 (1.377–79.476) | 0.023 | 11.154 (1.473–84.440) | 0.020 |
Histologic grade, 3, 4 (vs. 1, 2) | 23/34 | 10.462 (1.377–79.476) | 0.023 | 11.154 (1.473–84.440) | 0.020 |
Lymph node metastasis, presence (vs. absence) | 1/34 | 10.578 (1.100–101.706) | 0.041 | 6.224 (0.727–53.287) | 0.095 |
Distant metastasis, presence (vs. absence) | 5/34 | 5.324 (1.633–17.355) | 0.006 | 4.868 (1.495–15.853) | 0.009 |
Cy-FAM83H, positive (vs. negative) | 16/34 | 12.106 (2.736–53.563) | 0.001 | 14.253 (3.225–62.994) | < 0.001 |
Nu-FAM83H, positive (vs. negative) | 15/34 | 5.865 (1.874–18.355) | 0.002 | 6.294 (2.038–19.431) | 0.001 |
β-catenin, positive (vs. negative) | 13/34 | 4.225 (1.514–11.788) | 0.006 | 3.548 (1.328–9.485) | 0.012 |