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Table 3 Univariate Cox proportional hazards regression analysis for the overall survival and relapse-free survival of osteosarcoma patients

From: FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas

Characteristics No. OS RFS
HR (95% CI) P HR (95% CI) P
Age, years, ≥ 30 (vs. <  30) 10/34 2.730 (1.01–7.377) 0.048 2.959 (1.134–7.701) 0.027
Sex, male (vs. female) 24/34 1.900 (0.537–6.719) 0.320 2.223 (0.629–7.857) 0.215
Tumor size, ≥ 8 cm (vs. <  8 cm) 17/34 4.301 (1.369–13.508) 0.012 3.901 (1.351–11.260) 0.012
Stage, ≥ II (vs. I) 23/34 10.462 (1.377–79.476) 0.023 11.154 (1.473–84.440) 0.020
Histologic grade, 3, 4 (vs. 1, 2) 23/34 10.462 (1.377–79.476) 0.023 11.154 (1.473–84.440) 0.020
Lymph node metastasis, presence (vs. absence) 1/34 10.578 (1.100–101.706) 0.041 6.224 (0.727–53.287) 0.095
Distant metastasis, presence (vs. absence) 5/34 5.324 (1.633–17.355) 0.006 4.868 (1.495–15.853) 0.009
Cy-FAM83H, positive (vs. negative) 16/34 12.106 (2.736–53.563) 0.001 14.253 (3.225–62.994) < 0.001
Nu-FAM83H, positive (vs. negative) 15/34 5.865 (1.874–18.355) 0.002 6.294 (2.038–19.431) 0.001
β-catenin, positive (vs. negative) 13/34 4.225 (1.514–11.788) 0.006 3.548 (1.328–9.485) 0.012
  1. Abbreviations: Cy-FAM83H cytoplasmic expression of FAM83H, Nu-FAM83H nuclear expression of FAM83H, HR hazard ratio, 95% CI 95% confidence interval