Fig. 3
From: NKAP alters tumor immune microenvironment and promotes glioma growth via Notch1 signaling
Knockdown of NKAP attenuated growth of gliomas in combination with down-regulation of Notch1 in vivo. The U87 cells transduced with a lentiviral vector expressing si-NKAP were subcutaneous and orthotopic implanted into immunocompromised mice respectively. N = 5 in each group. a, Representative xenograft tumors at 35 days after inoculation. b, The line chart shows the estimated tumor volumes at the indicated time. c, Representative micrographs of H&E-stained sections of mouse brain tissue 35 days after intracranial implantation of U87 cells transfected with NKAP-siRNA or control vectors. d, Curves show the survival rates of the engrafted mice