Fig. 8
From: NKAP alters tumor immune microenvironment and promotes glioma growth via Notch1 signaling
Blockage of Notch1 attenuated the effects of NKAP on the TME of glioma. a and b, Inhibiting Notch1 signaling reduced the function of NKAP in promoting SDF-1 expression. c, Downregulation of Notch1 signaling weakened the function of NKAP in promoting M-CSF secretion. d, After inhibiting Notch1 signaling in U87 cells, the increased proportion of TAMs (CD206high CD80low) which co-incubated with NKAP overexpressed U87 cells was decreased compared to control group. Data are presented as the mean ± s.d. of three independent experiments. ***P < 0.001, **P < 0.01