Fig. 4

BEZ235 exerts antitumor effects in vivo in an NSCLC mouse xenograft model. a Mice with a subcutaneous H1975 cell xenograft tumor were orally administered 25 mg/kg BEZ235 daily. Volumes of tumors from vehicle control (●) and BEZ235 (■) groups (n = 8/group) were measured twice a week. Data are presented as means ± SEM (error bars; *, P < 0.05; Student’s t-test). Images of tumors (b) and weights of tumors (c) from mice with an H1975 cell xenograft after treatment with vehicle control or BEZ235 for 18 days. Data are presented as means ± SEM (error bars; *, P < 0.05; Student’s t-test)