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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K/AKT pathway

Fig. 3

HERG1 enhances migration and invasion of TE-1 and KYSE-30 cells. a Cell migration was assessed in wound healing assays. After 24 h, the wound was nearly closed upon HERG1 overexpression in TE-1 cells and was wider following HERG1 knockdown in KYSE-30 cells (n = 3). b In Boyden chamber invasion transwell assays, invasiveness was quantified by counting the cells invading through Matrigel into the bottom chamber (n = 3). c and d mRNA and protein levels of HERG1, E-cadherin, vimentin, and fibronectin in the different treatment groups were analyzed by qPCR (c) and western blotting (d); n = 3. (e) qPCR results showed that the expression of HERG1 was significantly correlated with that of the EMT markers, E-cadherin, vimentin, and fibronectin in samples of patients with ESCC; n = 20. *: p < 0.05

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