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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K/AKT pathway

Fig. 5

TXNDC5 expression in patients with ESCC, and its correlation with HERG1 and the clinicopathological characteristics of ESCC. Immunohistochemical staining of 349 primary ESCC specimens for TXNDC5 was performed using paraffin-embedded ESCC tissue specimens. a Representative images of TXNDC5 staining according to the TNM stage, T grade, N grade, and survival status of the patients (magnification, 200×). be TXNDC5 staining scores and frequency of high, medium, and low protein expression for TNM stages (b), T grades (c), N grades (d), and in relation to the survival of the patients (e); n = 349. (f) Positive correlation between the protein levels of HERG1 and TXNDC5 in the 349 ESCC specimens tested. (g) Kaplan–Meier analysis of the survival rates of patients with ESCC in relation to TXNDC5 protein expression (n = 349). (h) The log-rank test was used to assess the survival of patients with ESCC in relation to both high HERG1 and TXNDC5 expression, or both low HERG1 and TXNDC5 expression (n = 73). *: p < 0.05

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