Fig. 8

Diagram summarizing the role of HERG1 in promoting ESCC progression via TXNDC5. HERG1 promotes the phosphorylation of PI3K and AKT and, in turn, potentiates TXNDC5 expression, resulting in acceleration of the cell cycle process, inhibition of cell apoptosis, and induction of the EMT, consequently boosting ESCC cell proliferation, migration, and invasion, therefore affecting the prognosis of ESCC patients