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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux

Fig. 5

Knockdown of ATG4C promoted apoptosis and increased ROS accumulation in T98G cells. a-b The apoptosis in T98G cell transfected with si-ATG4C was detected by Annevin-V and Hoechst 33342 staining, respectively. c Changes in protein levels of cleaved-PARP, BAX and Bcl-2 expression in T98G cells transfected with ATG4C siRNAs. d Changes in Caspase-3/6/9 activity in T98G cells transfected with ATG4C siRNAs. e Changes in ROS levels in T98G cells transfected with ATG4C siRNAs. *p < 0.05, **p < 0.01, ***p < 0.001, NS: not significant

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