Fig. 8

High glucose promotes tumor growth in vivo via SREBP1. a Schematic presentation of the induction of type 2 diabetes in mice and establishment of subcutaneous transplantation tumors. b Blood glucose levels of mice in the normal glucose group and high glucose group. c Macroscopic pictures of tumors from the groups normal glucose + Si NC, normal glucose + Si SREBP1, high glucose + Si NC, and high glucose + Si SREBP1 (n = 5 each group). d The weights of tumors in different groups. e SREBP1 expression was detected by IHC. f P62, LC3, Bax and PCNA expression was detected by IHC. Scale bars = 100 μm. n = three independent experiments, *P < 0.05, **P < 0.01, or ***P < 0.001