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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells

Fig. 4

Napabucasin impairs the stemness of GBM cells. a GSCs from U87MG and LN229 cells were grown in serum-free DMEM/F12 medium with or without Napabucasin for 10 days. Sphere morphology was photographed under a light microscope and spheroids were counted. b GSCs under the indicated conditions were harvested and subjected to western blotting. c Transcriptional levels of stemness-associated markers (STAT3, β-catenin, c-Myc, Sox2, OCT4, and Nestin) in GSCs were determined by qPCR. (*p < 0.05, **p < 0.01, #p < 0.001)

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