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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells

Fig. 6

Napabucasin suppresses tumor growth in an orthotopic glioma model. a Changes in luciferase signals were detected at days 7, 14, and 21 after implantation of U87MG cells in situ (n = 6). The bioluminescent signal in the Napabucasin group was significantly lower than that in the vehicle group. b Survival differences between vehicle and Napabucasin groups shown by survival curves. The log-rank test was used to evaluate statistical differences. c Immunohistochemistry was used to assess the expression of STAT3, MMP2, Ki-67, cyclin D1, β-catenin, and c-Myc in orthotopic xenografted tumors after vehicle or Napabucasin treatments. (*p < 0.05, **p < 0.01, #p < 0.001)

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