Fig. 1

Microvascular structural entropy (MSE) might have potential as a biomarker of clinical outcomes. a Evaluation of MSE in liver cancer. b Relationship of metastasis and microvascular density (MVD) in 75 HCC tumor tissues, Student t test. c Pathological analysis the relationship of MSE and metastasis in 75 HCC tumor tissues. *, P < 0.05, Student t test. d Pathological analysis the relationship of MSE and clinical stage. *, P < 0.05; **, P < 0.01, one-way ANOVA. e Pathological analysis the relationship of MSE and pathologic grade. *, P < 0.05; **, P < 0.01, one-way ANOVA. f Kaplan–Meier plots of the overall survival rate of 75 patients with HCC with high MSE values and low MSE values group (P < 0.05). Results showed that patients with high MSE values have poor prognosis. g Correlation analysis of tumor tissues from 75 HCC cases between MSE and HIF1α, MMP2 and MMP9. MSE was positively correlated with HIF1α, MMP2 and MMP9 levels. Intergroup differences were assessed using Student’s t-tests. For all data, N.S., not significant, *P < 0.05, **P < 0.01