Fig. 6

Compound #3 sensitizes only HCC70 cells to Pt-compounds treatment. Histograms show the effect of co-treatments with CDDP (a, b) or CBDCA (c, d) and Compound #3 on viability of HCC70 (a-c) and HCC1937 (b, d) cells. Values express the mean viability ± SD from at least three independent replicates. Each value is normalized to the untreated condition. *p < 0.05, **p < 0.01, ***p < 0.001. A Bliss analysis, performed on these data, confirmed the existence of a synergistic effect of Compound #3 and Pt-salts on HCC70 cell line (data not shown)