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Table 1 List of IC50 values obtained for each TNBC cell type, type of drug, and timing response

From: APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC

Cell line Drug Time (hr) IC50 (μM)
HCC70 CDDP 24 5.72
HCC1937 29.6
HCC70 CBDCA 24 n.d. (> 100)
48 85.4
HCC1937 24 n.d. (> 100)
48 n.d. (interp = 171)
HCC70 Compound #3 24 2.96
48 3.17
HCC1937 24 n.d. (interp = 6)
48 3.09
HCC70 Fiduxosin 24 n.d. (> 20)
48 n.d. (> 20)
72 n.d. (> 20)
SB206553 24 n.d. (interp = 159)
48 n.d. (interp = 116)
72 68.1
Spiclomazine 24 50.2
48 n.d.
72 n.d.
HCC1937 Fiduxosin 24 n.d. (> 20)
48 n.d. (> 20)
72 n.d. (> 20)
SB206553 24 93.1
48 n.d. (> 100)
72 43.8
Spiclomazine 24 52.4
48 48.7
72 n.d.
  1. The analysis carried on by using the Combenefit 2.021 software allowed to calculate the IC50 values for each drug tested on the two analyzed TNBC and for different time points. n.d. means that the goodness of fit value is too low or a standard Hill equation does not correctly account for the specific agent used. In some cases, the expected interpolated IC50 value has been reported