Fig. 1

Arsenic trioxide (ATO) enhances the cytotoxic effect of homoharringtonine (HHT) in acute myeloid leukemia (AML) cell lines and primary CD34⁺ AML cells, and HHT and ATO synergistically damage leukemia stem-like cell lines and CD34⁺ primary cells (n = 3). Kasumi-1 cells (a), KG-1 cells (b), THP-1 cells (c), HEL cells (d), and primary CD34+ AML cells (e1, e2) were treated with HHT, ATO, or HHT + ATO for 2 days, and cell viability was measured by the CCK-8 assay. IC50 of HHT is calculated by using SPSS 22 (f,g,h). Error bars represent standard deviations of three independent experiments. P < 0.05*, P < 0.01**, P < 0.001***