Fig. 1
From: CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis
CDK5 is increased in HCC and correlates with postoperative survive. a Immunoblotting analysis of CDK5 protein expression in HCC tissue specimens(T) and non-cancerous surrounding tissues(N), The ratios of CDK5 in HCC tumors compared to paired non- cancerous tissue controls (T/N) from 60 patients are presented in the right panel. b Immunohistochemistry of CDK5 in HCC tissue specimens and respective non-tumor tissue specimens (NT). Samples were classified into two groups according to CDK5 expression: CDK5 positive group (T > N,66 of the 90(73.3%)) and negative group (T ≤ N,24 of the 90(26.7%)). c Real-time PCR analysis of CDK5 mRNA expressionin HCC tumor and corresponding nontumortissues. Ratios of HCC tumor compared to respectivenon-tumor tissue (T/N) from 86 patients are presented. d Kaplan-Meier survival curves of “High CDK5” and “Low CDK5” group HCC patients