Fig. 5

Cathepsin L-mediated resistance of paclitaxel and cisplatin via distinct regulatory mechanisms in two other non-small lung cancer. a and c PC9 and H460 cells were treated with different concentration of paclitaxel and harvested at 12 h, 24 h and 48 h, and western blot detected the expression level of CTSL and TGF-β/smad signaling pathway associated proteins. b and d PC9 and H460 cells were treated with different concentration of cisplatin and harvested at 12 h, 24 h and 48 h, and western blot detected the expression level of CTSL, Egr-1 and CREB. At least three independent experiments were performed