ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation

Table 2 Cox regression analysis of OSCC survival

Variable	Univariate survival analysis			Multivariate survival analysis
Variable	HR	95% CI	P	HR	95% CI	P
Gender (male, female)	0.926	0.464–1.850	0.828	N/A	N/A	N/A
Age (≤60, > 60)	0.746	0.380–1.464	0.394	N/A	N/A	N/A
Smoking (no, yes)	2.11	1.076–4.140	0.03	0.919	0.419–2.015	0.833
T category (T1 + T2, T3 + T4)	5.747	2.673–12.358	< 0.001	8.381	3.453–20.341	< 0.001
N category (N0, N+)	4.8	2.287–10.078	< 0.001	7.405	2.002–27.388	< 0.001
TNM stage (I + II, III + IV)	4.478	1.945–10.312	< 0.001	0.444	0.105–1.873	0.269
Histology grade (1, 2 + 3)	1.746	0.864–3.531	0.121	0.668	0.296–1.509	0.332
ADAR1 expression (Low, High)	6.459	2.666–15.650	< 0.001	5.085	1.936–13.353	0.001

ADAR1 Adenosine deaminases acting on RNA, OSCC Oral squamous cell carcinoma, HR Hazard ratio, 95%CI 95% confidence interval, P P value, T Tumor size, N Lymph node, TNM Tumor-node-metastases. Both values signify P-value < 0.05

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