Fig. 3
a Kinetic bio-distribution of anti-HER2 gold nanoshells (GNs) after intravenous administration of 3.5 × 1013 nanoshells in mice using magnetic resonance imaging (MRI). Results are expressed as percentages of initial signal variations (ΔSI), each signal intensity being compared with a pre-contrast signal. b Absolute gold concentration in blood and tissue samples after intravenous administration of 3.5 × 1013 anti-HER2 GNs using ICP-MS. Data is expressed as mean ± standard deviation, and comparisons between the liver and spleen concentrations were made using Student’s t-test (*P < 0.05). c Dark field images of tissue sections obtained from the liver and spleen after injection of anti-HER2 GNs. d TEM images of anti-HER2 GNs internalized in liver and spleen cells