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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment-related genes

Fig. 5

MiR-361 downregulates the expression of prometastatic genes and microenvironment-related genes. (a) Predicted interactions between miR-361 and the 3′-UTRs of the indicated genes. (b) Luciferase reporter assays using SPAC-1-L cells cotransfected with the indicated luciferase reporters and miR-361 mimic or HI cells cotransfected with the indicated luciferase reporters and miR-361 inhibitor. (c) Western blot analysis of the indicated proteins in SPAC-1-L cells cotransfected with control or miR-361 mimic with or without a MEF2D, ROCK1, WNT7A or KPNA4 expression vector. (d) Cell invasion and sphere formation abilities of SPAC-1-L cells cotransfected with control or miR-361 mimic with or without an MEF2D, ROCK1, WNT7A or KPNA4 expression vector. *P < 0.05

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