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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment-related genes

Fig. 7

MiR-361 modulates the ability of NEAT1 to promote aggressive EC progression. (a, b) Cell invasion and sphere formation abilities of control or NEAT1-silenced SPAC-1-L (a) and HI (b) cells transfected with or without a miR-361 inhibitor. (c) qRT-PCR analysis of the indicated miR-361 target genes in control or NEAT1-silenced SPAC-1-L (a) and HI (b) cells transfected with or without a miR-361 inhibitor. (d, e) Xenograft tumor formation in nude mice injected with control or NEAT1-silenced SPAC-1-L cells transfected with or without a miR-361 inhibitor. Growth curves (d) and tumor weights (e). (f) Total RNA from tumor tissue analyzed by qRT-PCR assays to determine the mRNA levels of the indicated miR-361 target genes. *P < 0.05

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