Fig. 2From: IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinomaPhenotypic features of NK cells from the peripheral blood of normal volunteers and peripheral blood, tumour and tumour-adjacent tissues of ESCC patients. a Peripheral blood-, tumour- and adjacent tissue-derived cell suspensions were stained with Abs to CD3, CD56, CD16, NKp30, NKp44, NKp46, NKG2D, CD226, NKG2A, and CD158b. NK cells were gated as CD3-CD56+ events, and the expression levels of CD16, NKp30, NKp44, NKp46, NKG2D, CD226, NKG2A, and CD158b were then analysed. b Symbols represent individual values from 9 to 21 ESCC patients or volunteers analysed individually, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. Functional characteristics of NK cells in ESCC patients. c Representative dot plots of KI67, granzyme B, and perforin expression levels in NK cells from the peripheral blood of normal volunteers and paired patient blood, tumour-adjacent and tumour tissues from each ESCC patient. d Statistical analysis of KI67+, granzyme B+, and perforin+ NK cell percentages. Symbols represent individual values from 15 to 16 ESCC patients or volunteers analysed individually. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. Each experiment was repeated three timesBack to article page