Fig. 5

In silico analysis for differentially expressed genes and regulatory miRNAs related to PDAC treated with macrophages. a-c heat maps of differentially expressed genes obtained from gene expression datasets with macrophage-treated PDAC samples and common PDAC datasets. The abscissa represents the sample number, and the ordinate represents the differential expressed gene; the histogram at the left refers to gene expression cluster, and the histogram at the upper right refers to color gradation. d the intersection of the gene expression datasets analysis. The three circles in the panel represent the down-regulated genes in the three gene expression datasets, and the middle part represents the intersection of the three sets of data. e the expression of TGFBR3 in each tumor data of TCGA database. The abscissa indicates the sample type and tumor type, and the ordinate indicates the gene expression. f prediction of regulatory miRNAs of TGFBR3. The two sets of data in the panel are retrieved from the TargetScan database prediction and the study revealing miRNAs expressed in macrophage exosomes, and the middle part represents the intersection of the two sets of data