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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway

Fig. 7

TGF-β signaling pathway is involved in the effect of miR-501-3p on PDAC cells. a and b Western blot analysis was used to detect the TGF-β signaling pathway-related proteins in PANC-1 cells after Mp-Exo treatment. c and d Western blot analysis was applied to detect the TGF-β signaling pathway-related proteins in PANC-1 cells treated with oe-TGFBR3. e and f Western blot analysis was conducted to detect the TGF-β signaling pathway-related proteins in BxPC-3 cells after Mp-Exo treatment. g and h Western blot analysis was used to detect the TGF-β signaling pathway-related proteins in BxPC-3 cells treated with oe-TGFBR3. i and j Western blot analysis was applied to detect the TGF-β signaling pathway-related proteins in PANC-1 cells after treatment of miR-501-3p mimic, inhibitor or TGFBR3 siRNA. k and l Western blot analysis was used to detect the TGF-β signaling pathway-related proteins in BxPC-3 cells after treatment of miR-501-3p mimic, inhibitor or TGFBR3 siRNA. * p < 0.05 vs. control, vector or NC mimic. # p < 0.05 vs. NC inhibitor. & p < 0.05 vs. NC siRNA. The measurement data were expressed as mean ± standard deviation. Data between two groups were analyzed by independent sample t test. One-way ANOVA was employed for comparison among multiple groups, followed by Tukey’s post-hoc test. Cell experiments were repeated three times

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