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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Long non-coding RNA LUCAT1/miR-5582-3p/TCF7L2 axis regulates breast cancer stemness via Wnt/β-catenin pathway

Fig. 6

The regulatory mechanism of LUCAT1/miR-5582-3p/TCF7L2 axis and Wnt/β-catenin pathway in vivo. a Subcutaneous tumor was taken in four groups. b The isolated tumors were separated from xenograft mice. c Average tumor volumes were measured in xenograft mice every two days. d Images of average tumor weight at the end of indicated treatment. e Wnt/β-catenin signaling pathway-related protein expression (total TCF7L2 and Wnt1 proteins, total and nuclear β-catenin proteins) and SOX2 were measured in four groups by western blot. f TCF7L2 and SOX2 protein levels were detected in tumor tissues in four groups by IHC. Original magnification, × 400. Scale bars, 50 μm. Data are presented as the mean ± SD of three independent experiments performed in triplicate. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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