Fig. 6

αV-integrin detection in human PCa tissues reveals LO like vesicles and correlates with prognosis. αV- integrin staining of human PCa tissues, performed by immunohystochemistry. a Benign tissues (Normal Prostate Epithelia, NPE), prostatic intraepithelial neoplasia (PIN); tumor tissues (Gleason Score = 6; Gleason Score = 8, GS6 and GS8, respectively). All images are 20× magnified in the upper panels; 60× magnified in lower panels. b Negative controls: PCa tissue sample stained only with secondary Ab; inset: lymph node negative for tumor cells stained with αV-integrin Ab. αV-integrin expression correlated with (c) Gleason score grading (**p = 0,005) and (d) lymph nodes metastasis (***p = 0,001)