Fig. 2

IDO1 involved pathways based on GSEA and WGCNA analysis in GC. a GSEA analysis showed IDO1-related KEGG pathways in GC tissue of TCGA database (High expression group (n = 207) vs Low expression group (n = 208), P < 0.01, FDR < 0.01). b Identification of gene co-expression modules using transcriptomic data of GC cell lines in CCLE by average hierarchical linkage clustering; the y-axis and x-axis represented the co-expression distance and genes respectively. Modules were identified using dynamic tree cutting by dividing the dendrogram at significant branch points. Modules were displayed with different colors below the dendrogram, and gray modules indicated unassigned genes. c The correlation coefficients between IDO1 mRNA level and different modules. d WGCNA analysis was performed using the genes in brown module. Five hub genes (AXL, SGCE, COL12A1, ANTXR1 and LOXL2) with the degree ≥160 were identified in brown module by Cytoscape software. e The expression levels of AXL, SGCE, COL12A1, ANTXR1 and LOXL2 in 32 paired gastric normal and cancer tissues in TCGA database