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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: A positive feedback between IDO1 metabolite and COL12A1 via MAPK pathway to promote gastric cancer metastasis

Fig. 4

COL12A1 is identified as a critical cancer-promoting gene enhancing migratory capacity of GC cell. a Western blot was utilized to detect expression of LOXL2, CLO6A1, COL6A2 and COL12A1 after transfecting specific siRNAs in SGC-7901 and HGC-27. b COL12A1, LOXL2, COL6A1 and COL6A2 were silenced by IDO1, COL12A1, LOXL2, COL6A1 and COL6A2 siRNAs transfection. Three days later, IDO1, COL12A1, LOXL2, COL6A1 and COL6A2 proteins were detected by Western blot. c Effects of knockdown of LOXL2, COL6A1, COL6A2 and COL12A1 on SGC-7901 and HGC-27 migratory capacity. “*” represented comparing with “NC” group. **P < 0.01, ***P < 0.001

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