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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4

Fig. 4

Notch1 is required for invasion, migration properties and self-renewal of GICs by CXCL12/CXCR4 system. a-b Morphology of tumor spheres formed by the cancer initiating cells from U87 and U251 glioma cells. And Quantitative analysis were shown respectively. c In vitro limiting dilution assay of U87GICs and U251GICs in negative control, shRNA-Notch1 and shNotch1 + CXCL12 groups. d-g Transwell assay of U87GICs and U251GICs in negative control, shRNA-Notch1 and shNotch1 + CXCL12 groups. And Quantitative analysis were shown respectively. (*P < 0.05, **P < 0.01, ***P < 0.001)

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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