Fig. 7
Silencing of Notch1 inhibits tumor growth and invasion in vivo. a Schematic diagram of Intracranial implantation of U87-GICs expressing shNotch1 or shNC. b The representative bioluminescent images of the tumor-bearing mice implanted with U87-GICs. c Mouse weight was recorded as a measure of mouse nutrition in the two groups. d Kaplan–Meier survival curve was used to detect differences in mouse survival times between the two groups. e Immunohistochemistry analysis of the expression of Notch1, CXCR4 and pAKT in Notch1-shRNA treated tumors compared to tumors in the shNC group. f Representative images of H&E staining of tumor border from mice 3 weeks after tumor implantation (black triangle: disseminated tumors)